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Amphetamine is thought to inhibit monoamine oxidase, While the flexibility of amphetamine and its metabolites to inhibit a variety of P450 isozymes and various enzymes has not been adequately elucidated. In vitro experiments with human microsomes show slight inhibition of CYP2D6 by amphetamine and insignificant inhibition of CYP1A2, 2D6, and 3A4 by